Alternate Costumes
| Unlockable | How to Unlock |
|---|---|
| Barry (American) | Get 20 Medals |
| Chris (Pilot) | Mission Level 1-3 get an SS-rank, or get 10 Medals |
| Claire (Suit) | Get 25 Medals |
| HUNK (Reaper) | Get all A-rank on all Mission Level (except Level Ex) |
| Jill (RE3) | Get an S-rank on Mission Level 3-5 |
| Krauser (Exoskaleton) | Get S-rank on Mission Level 5-5 |
| Rebacca (Nurse) | Get all S-rank on all Mission Level (except Level Ex) |
| Wesker (Uroboros) | Get a B-rank or above for all Mission |
Character's Weapons
To make a particular character's weapons accessible to every other characters, score SS rank using the character on every Missions up to Mission 5-5. Alternatively, you can spend 10 Nintendo 3DS Play Coins to unlock the character's weapons.
Characters
| Unlockable | How to Unlock |
|---|---|
| Barry | Clear Mission 4-5 with a B rank |
| Claire | Clear Mission 1-3 with a B rank |
| Krauser | Clear Mission 3-5 with a B rank |
| Rebecca | Clear Mission 2-3 with a B rank |
| Wesker | Clear Mission 5-5 with a B rank |
EX Missions
Once you clear mission 5-5 with atleast B rank the credits should roll. After watching the credits the EX Missions should be available.
Unlockable Skills
| Unlockable | How to Unlock |
|---|---|
| Handgun Technique | Clear Mission 4-1 with a B rank |
| Machine Gun Technique | Clear Mission 4-3 with a B rank |
| Maximizer | Clear Mission 4-4 with a B rank |
| Medic | Clear Mission 1-3 with a B rank |
| Revenge | Clear Mission 4-2 with a B rank |
Glitches
Instantly Obtain 300 Green Herbs
Make sure that you have zero green herbs in your inventory. Locate a green herb and pick it up while using it (on the default control scheme, press the Y and A buttons simultaneously). If your timing was correct, the game will have tried to subtract one herb from a total of zero. This will cause the inventory counter to cyclically roll backwards to its maximum amount, resulting in 300 green herbs available for use. Note that this method will not work online.
